Immunotherapy Targeting Folate Receptor Induces Cell Death Associated with Autophagy in Ovarian Cancer
نویسندگان
چکیده
منابع مشابه
Immunotherapy targeting folate receptor induces cell death associated with autophagy in ovarian cancer.
PURPOSE Cancer cells are highly dependent on folate metabolism, making them susceptible to drugs that inhibit folate receptor activities. Targeting overexpressed folate receptor alpha (FRα) in cancer cells offers a therapeutic opportunity. We investigated the functional mechanisms of MORAB-003 (farletuzumab), a humanized mAb against FRα, in ovarian cancer models. EXPERIMENTAL DESIGN We first ...
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ژورنال
عنوان ژورنال: Clinical Cancer Research
سال: 2014
ISSN: 1078-0432,1557-3265
DOI: 10.1158/1078-0432.ccr-14-1578